APromoterPromoter Activity Atlas
Computational regulatory genomics
A promoter activity atlas built to move from biological context to testable regulatory sequence designs.
APromoter brings promoter profiles, tissue-aware prediction, comparative analysis, and sequence engineering into one research environment. It is developed as part of APSCS by Nie L.
APromoter organizes promoter activity by tissue, assay target, reference construct and model configuration. These details define each comparison and make results interpretable in their biological context.
Researchers can explore the atlas, compare predicted activity across panels and prioritize sequences for experimental testing.
From reference data to sequence candidates
Search promoter records and inspect predicted activity across tissues, cells, and curated biological panels.
A virtual assay harness for multi-omics foundation models. VirDLA assembles reporter constructs, calls the model and computes relative activity to evaluate candidates in the VirEvo design loop.
Run context-aware prediction, consistency filtering, contribution analysis, and configurable sequence evolution workflows.
Compare model predictions with SHARPR-MPRA measurements using model-specific correlations, prediction distributions and reproducible benchmark artifacts.
Current manuscript
VirDLA + APromoter Atlas · 2026
Manuscript draft · Available to read online
Citing the platform. Until the preprint is available, cite the APromoter website with its access date and record the Atlas release, model backend, panel, reference construct, and software configuration used in the analysis.
APromoter / APSCS
